Predictors of specialized intestinal metaplasia in patients with an incidental irregular Z line

Ram Dickman, Zohar Levi, Alex Vilkin, Ibrahim Zvidi, Yaron Niv

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Iitroduction: Barrett's esophagus is a well-known complication of gastroesophageal reflux disease (GERD) and is associated with dysplasia and esophageal adenocarcinoma. Data on the prevalence of specialized intestinal metaplasia (SIM) in biopsy taken from an incidental irregular Z line are scarce. AIM: To determine the prevalence of SIM in biopsies taken from an incidental irregular Z line in consecutive patients undergoing upper endoscopy. Methods: During the study period, we identified all adult patients who underwent an upper endoscopy with biopsies from an incidental finding of an irregular Z line. Demographic characteristics, prevalence of endoscopic findings, and major complaints were compared between those with SIM and those without. Results: A total of 166 out of 2000 (8.3%) consecutive patients were identified. Specialized intestinal metaplasia was found in 43.5% of all cases. Male sex and the presence of hiatus hernia were predictors of SIM (P≤0.043 and 0.001, respectively), with relative risks of 2.02 (95% confidence interval: 1.01-4.0) and 3.31 (95% confidence interval: 1.66-6.58), respectively. Conclusion: In this endoscopic and histological study, SIM was found to be a common finding in patients with irregular Z line. Male sex and the presence of diaphragmatic hernia were significantly associated with the presence of SIM.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume22
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Barrett's esophagus
  • Gastroesophageal reflux disease
  • Irregular Z line
  • Reflux
  • Specialized intestinal metaplasia

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