Platelet-rich plasma did not improve early healing of medial collateral ligament in rats

Eyal Amar, Nimrod Snir, Osnat Sher, Tamar Brosh, Morsi Khashan, Moshe Salai, Oleg Dolkart

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: The medial collateral ligament (MCL) is the most frequently injured ligament of the knee. Platelet-rich plasma (PRP) is a relatively new treatment option developed to enhance the healing response after injury to different tissue types. This study aimed at investigating whether the addition of PRP to MCL tears in rats would alter healing both biomechanically and histologically. Methods: Bilateral full-thickness tears of the MCL were surgically induced in the knees of 32 rats. Right ligament was saturated with PRP (n = 32, study group), and the left ligament was saturated with saline (n = 32, control group). The animals were killed 3 weeks later and the surgical sites were evaluated by gross inspection, biomechanically and histologically. Results: There was no gross difference in the mass of granulation tissue, load to failure, stiffness and displacement between the study and control groups. Histological examination by means of maturity score revealed no significant differences between the study and control groups. Conclusion: The addition of PRP to a healing MCL did not improve any of the outcome measures in this model.

Original languageEnglish
Pages (from-to)1571-1577
Number of pages7
JournalArchives of Orthopaedic and Trauma Surgery
Issue number11
StatePublished - 1 Nov 2015
Externally publishedYes


  • Early healing
  • Medial collateral ligament
  • Platelet-rich plasma


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