Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel

Shiri Navon-Venezia, Inna Chmelnitsky, Azita Leavitt, Mitchell J. Schwaber, David Schwartz, Yehuda Carmeli

Research output: Contribution to journalArticlepeer-review

158 Scopus citations

Abstract

Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

Original languageEnglish
Pages (from-to)3098-3101
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Dive into the research topics of 'Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel'. Together they form a unique fingerprint.

Cite this