Pituitary-adrenal responses to arm versus leg exercise in untrained man

Carl M. Maresh, Bülent Sökmen, William J. Kraemer, Jay R. Hoffman, Greig Watson, Daniel A. Judelson, Catherine L. Gabaree-Boulant, Michael R. Deschenes, Jaci L. VanHeest, Lawrence E. Armstrong

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The purpose of this study was to examine pituitary-adrenal (PA) hormone responses [beta-endorphin (β-END), adrenocorticotropic hormone (ACTH) and cortisol] to arm exercise (AE) and leg exercise (LE) at 60 and 80% of the muscle-group specific VO2 peak. Eight healthy untrained men (AE VO2 peak = 32.4±3.0 ml kg-1 min-1, LE VO2 peak = 46.9±5.3 ml kg-1 min-1) performed two sub-maximal AE and LE tests in random order. Plasma β-END, ACTH and cortisol were not different (P>0.05) between AE and LE at either exercise intensity; the 60% testing elicited no changes from pre-exercise (PRE) values. For 80% testing, plasma β-END, ACTH and cortisol were consistently, but not significantly, greater during LE than AE. In general, plasma β-END and ACTH were higher (P<0.05) during 80% exercise, than PRE, for both AE and LE. Plasma cortisol was elevated (P<0.05) above PRE during 80% LE, and following 80% for both AE and LE. Plasma ACTH was higher (P<0.05) during 80% LE and AE versus 60% LE and AE, respectively. Plasma β-END and cortisol were significantly higher during and immediately after 80% LE than 60% LE. Thus, plasma β-END, ACTH and cortisol responses were similar for AE and LE at the two relative exercise intensities, with the intensity threshold occurring somewhere between 60 and 80% of VO2 peak. It appears that the smaller muscle mass associated with AE was sufficient to stimulate these PA axis hormones in a manner similar to LE, despite the higher metabolic stress (i.e., plasma La-) associated with LE.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalEuropean Journal of Applied Physiology
Issue number4
StatePublished - Jul 2006
Externally publishedYes


  • Adrenocorticotropic hormone
  • Beta-endorphin
  • Cortisol
  • Muscle-group specific VOpeak


Dive into the research topics of 'Pituitary-adrenal responses to arm versus leg exercise in untrained man'. Together they form a unique fingerprint.

Cite this