TY - JOUR
T1 - Physical Working Capacity at Fatigue Threshold (PWCFT) is Associated with Sarcopenia-Related Body Composition and Measures of Functionality in Older Adults
AU - Emerson, Nadia S.
AU - Fukuda, David H.
AU - Stout, Jeffrey R.
AU - Robinson, Edward H.
AU - McCormack, William P.
AU - Scanlon, Tyler C.
AU - Warren, Ashlee M.
AU - Wells, Adam J.
AU - Gonzalez, Adam M.
AU - Mangine, Gerald T.
AU - Fragala, Maren S.
AU - Hoffman, Jay R.
N1 - Publisher Copyright:
© 2014.
PY - 2014
Y1 - 2014
N2 - The relationship between physical working capacity at fatigue threshold (PWCFT) and common measures used to assess sarcopenia in older adults were examined. Fifty-eight older adults (age: 71.1±6.2 y; BMI: 28.0±5.4kg/m2) completed the testing procedures. Sarcopenia-related body composition was measured by dual-energy x-ray absorptiometry and participants performed a discontinuous cycle ergometry test to determine PWCFT. Functionality assessments included maximal isometric grip strength (GRIP) and sit-to-stand (STS) repetitions in 30seconds. Muscle quality (MQ) was defined as GRIP relative to appendicular lean soft tissue (ALST), while skeletal muscle index (SMI) was defined as ALST/height2. Pearson correlations were used to examine the relationships among dependent variables. PWCFT showed significant relationships with ALST (r=0.57), SMI (r=0.47), body fat percentage (r=-0.50), GRIP (r=0.49), and STS (r=0.44). For follow-up analyses, study participants were categorized into low sarcopenia risk (n=31) or high sarcopenia risk (n=27) groups by SMI. Sarcopenia risk was associated with PWCFT [odds ratio (OR): 1.051, 95% confidence interval (CI): 1.016-1.087] and STS (OR: 1.305, CI: 1.060-1.607), but not GRIP (OR: 1.098, CI: 0.989-1.218). Using receiver operator characteristic curve analysis, both PWCFT [area under the curve (AUC): 0.737, CI: 0.608-0.866, optimal cutoff: 37.5 watts] and STS (AUC: 0.749, CI: 0.623-0.874, optimal cutoff: 12.5 repetitions] showed discriminative ability with regard to sarcopenia risk. The current data suggest that the neuromuscular fatigue threshold, as measured by PWCFT, is related to measures of body composition and function in older adults.
AB - The relationship between physical working capacity at fatigue threshold (PWCFT) and common measures used to assess sarcopenia in older adults were examined. Fifty-eight older adults (age: 71.1±6.2 y; BMI: 28.0±5.4kg/m2) completed the testing procedures. Sarcopenia-related body composition was measured by dual-energy x-ray absorptiometry and participants performed a discontinuous cycle ergometry test to determine PWCFT. Functionality assessments included maximal isometric grip strength (GRIP) and sit-to-stand (STS) repetitions in 30seconds. Muscle quality (MQ) was defined as GRIP relative to appendicular lean soft tissue (ALST), while skeletal muscle index (SMI) was defined as ALST/height2. Pearson correlations were used to examine the relationships among dependent variables. PWCFT showed significant relationships with ALST (r=0.57), SMI (r=0.47), body fat percentage (r=-0.50), GRIP (r=0.49), and STS (r=0.44). For follow-up analyses, study participants were categorized into low sarcopenia risk (n=31) or high sarcopenia risk (n=27) groups by SMI. Sarcopenia risk was associated with PWCFT [odds ratio (OR): 1.051, 95% confidence interval (CI): 1.016-1.087] and STS (OR: 1.305, CI: 1.060-1.607), but not GRIP (OR: 1.098, CI: 0.989-1.218). Using receiver operator characteristic curve analysis, both PWCFT [area under the curve (AUC): 0.737, CI: 0.608-0.866, optimal cutoff: 37.5 watts] and STS (AUC: 0.749, CI: 0.623-0.874, optimal cutoff: 12.5 repetitions] showed discriminative ability with regard to sarcopenia risk. The current data suggest that the neuromuscular fatigue threshold, as measured by PWCFT, is related to measures of body composition and function in older adults.
KW - Aging
KW - Disability
KW - Neuromuscular function
KW - Skeletal muscle index
UR - http://www.scopus.com/inward/record.url?scp=84921634612&partnerID=8YFLogxK
U2 - 10.1016/j.archger.2014.04.012
DO - 10.1016/j.archger.2014.04.012
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C2 - 24856645
AN - SCOPUS:84921634612
SN - 0167-4943
VL - 59
SP - 300
EP - 304
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
IS - 2
ER -