Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus

Yuval Heled, Yair Shapiro, Yoav Shani, Dani S. Moran, Lea Langzam, Liora Braiman, Sanford R. Sampson, Joseph Meyerovitch

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We hypothesized that exercise training might prevent diabetes mellitus in Psammomys obesus. Animals were assigned to three groups: high-energy diet (CH), high-energy diet and exercise (EH), and low-energy diet (CL). The EH group ran on a treadmill 5 days/wk, twice a day. After 4 wk, 93% of the CH group were diabetic compared with only 20% of the EH group. There was no difference in weight gain among the groups. Both EH and CH groups were hyperinsulinemic. Epididymal fat (% of body weight) was higher in the CH group than in either the EH and or the CL group. Protein kinase C (PKC)-δ activity and serine phosphorylation were higher in the EH group. No differences were found in tyrosine phosphorylation of the insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase among the groups. We demonstrate for the first time that exercise training effectively prevents the progression of diabetes mellitus type 2 in Psammomys obesus. PKC-δ may be involved in the adaptive effects of exercise in skeletal muscles that lead to the prevention of type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)E370-E375
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number2 45-2
StatePublished - 2002
Externally publishedYes


  • Physical exercise
  • Protein kinase C-δ
  • Psammomys obesus
  • Type 2 diabetes mellitus


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