Pharmacokinetics of oral and intravenous bromide in normal volunteers

The pharmacokinetics of oral and intravenous bromide was studied in 7 adult volunteers, who served as their own controls. They received 1 ml/kg of 3% sodium bromide, equivalent to 30 mg/kg bromide. Oral bioavailability ranged between 75-118% with a mean of 96 ± 6% Elimination T_1/2 was 11.9 ± 1.4 days after oral administration and 9.4 ± 1.5 days after I.V. administration (P > 0.10). The employment of this ion for calculation of extracellular fluid and assessment of its potential significance in environmental toxicology necessitates accurate data on its disposition characteristics.