Pharmacokinetics of oral and intravenous bromide in normal volunteers

Nachum Vaiseman, Gideon Koren, Paul Pencharz

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The pharmacokinetics of oral and intravenous bromide was studied in 7 adult volunteers, who served as their own controls. They received 1 ml/kg of 3% sodium bromide, equivalent to 30 mg/kg bromide. Oral bioavailability ranged between 75-118% with a mean of 96 ± 6% Elimination T1/2 was 11.9 ± 1.4 days after oral administration and 9.4 ± 1.5 days after I.V. administration (P > 0.10). The employment of this ion for calculation of extracellular fluid and assessment of its potential significance in environmental toxicology necessitates accurate data on its disposition characteristics.

Original languageEnglish
Pages (from-to)403-413
Number of pages11
JournalClinical Toxicology
Volume24
Issue number5
DOIs
StatePublished - 1986
Externally publishedYes

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