Abstract
The pharmacokinetics of oral and intravenous bromide was studied in 7 adult volunteers, who served as their own controls. They received 1 ml/kg of 3% sodium bromide, equivalent to 30 mg/kg bromide. Oral bioavailability ranged between 75-118% with a mean of 96 ± 6% Elimination T1/2 was 11.9 ± 1.4 days after oral administration and 9.4 ± 1.5 days after I.V. administration (P > 0.10). The employment of this ion for calculation of extracellular fluid and assessment of its potential significance in environmental toxicology necessitates accurate data on its disposition characteristics.
Original language | English |
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Pages (from-to) | 403-413 |
Number of pages | 11 |
Journal | Clinical Toxicology |
Volume | 24 |
Issue number | 5 |
DOIs | |
State | Published - 1986 |
Externally published | Yes |