Perspectives on hand function in girls and women with Rett syndrome

Jenny Downs, Stephanie Parkinson, Sonia Ranelli, Helen Leonard, Pamela Diener, Meir Lotan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objective: Rett syndrome is a rare neurodevelopmental disorder that is usually associated with a mutation on the X-linked MECP2 gene. Hand function is particularly affected and we discuss theoretical and practical perspectives for optimising hand function in Rett syndrome. Methods: We reviewed the literature pertaining to hand function and stereotypies in Rett syndrome and developed a toolkit for their assessment and treatment. Results: There is little published information on management of hand function in Rett syndrome. We suggest assessment and treatment strategies based on available literature, clinical experience and grounded in theories of motor control and motor learning. Conclusion: Additional studies are needed to determine the best treatments for hand function in Rett syndrome. Meanwhile, clinical needs can be addressed by supplementing the evidence base with an understanding of the complexities of Rett syndrome, clinical experience, environmental enrichment animal studies and theories of motor control and motor learning.

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalDevelopmental Neurorehabilitation
Volume17
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • Hand function
  • MECP2
  • Rett syndrome
  • Stereotypies

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