Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies

Nadav Furie; Michal Mandelboim; Neta Zuckerman; Ana Belkin; Lior Seluk; Inbal Shafran; Ronen Mass; Liran Levy; Sumit Chatterji; Erik Baltaxe; Michael Peled; Tiberiu Shulimzon; Abraham Avigdor; Sharon Amit; Amir Onn; Edith M. Marom; Galia Rahav; Michael J. Segel

doi:10.1093/ofid/ofad464

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies

Nadav Furie
, Michal Mandelboim
, Neta Zuckerman
, Ana Belkin
, Lior Seluk
, Inbal Shafran
, Ronen Mass
, Liran Levy
, Sumit Chatterji
, Erik Baltaxe
, Michael Peled
, Tiberiu Shulimzon
, Abraham Avigdor
, Sharon Amit
, Amir Onn
, Edith M. Marom
, Galia Rahav
, Michael J. Segel

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

Original language	English
Article number	ofad464
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofad464
State	Published - 1 Oct 2023
Externally published	Yes

Keywords

COVID19
SARS-CoV-2
antibody therapy
immune globulins
monoclonal antibody

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10.1093/ofid/ofad464

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Furie, N., Mandelboim, M., Zuckerman, N., Belkin, A., Seluk, L., Shafran, I., Mass, R., Levy, L., Chatterji, S., Baltaxe, E., Peled, M., Shulimzon, T., Avigdor, A., Amit, S., Onn, A., Marom, E. M., Rahav, G., & Segel, M. J. (2023). Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies. Open Forum Infectious Diseases, 10(10), Article ofad464. https://doi.org/10.1093/ofid/ofad464

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title = "Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies",

abstract = "We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.",

keywords = "COVID19, SARS-CoV-2, antibody therapy, immune globulins, monoclonal antibody",

author = "Nadav Furie and Michal Mandelboim and Neta Zuckerman and Ana Belkin and Lior Seluk and Inbal Shafran and Ronen Mass and Liran Levy and Sumit Chatterji and Erik Baltaxe and Michael Peled and Tiberiu Shulimzon and Abraham Avigdor and Sharon Amit and Amir Onn and Marom, \{Edith M.\} and Galia Rahav and Segel, \{Michael J.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = oct,

day = "1",

doi = "10.1093/ofid/ofad464",

language = "אנגלית",

volume = "10",

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Furie, N, Mandelboim, M, Zuckerman, N, Belkin, A, Seluk, L, Shafran, I, Mass, R, Levy, L, Chatterji, S, Baltaxe, E, Peled, M, Shulimzon, T, Avigdor, A, Amit, S, Onn, A, Marom, EM, Rahav, G & Segel, MJ 2023, 'Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies', Open Forum Infectious Diseases, vol. 10, no. 10, ofad464. https://doi.org/10.1093/ofid/ofad464

TY - JOUR

T1 - Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies

AU - Furie, Nadav

AU - Mandelboim, Michal

AU - Zuckerman, Neta

AU - Belkin, Ana

AU - Seluk, Lior

AU - Shafran, Inbal

AU - Mass, Ronen

AU - Levy, Liran

AU - Chatterji, Sumit

AU - Baltaxe, Erik

AU - Peled, Michael

AU - Shulimzon, Tiberiu

AU - Avigdor, Abraham

AU - Amit, Sharon

AU - Onn, Amir

AU - Marom, Edith M.

AU - Rahav, Galia

AU - Segel, Michael J.

PY - 2023/10/1

Y1 - 2023/10/1

N2 - We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

AB - We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

KW - COVID19

KW - SARS-CoV-2

KW - antibody therapy

KW - immune globulins

KW - monoclonal antibody

UR - https://www.scopus.com/pages/publications/85174970945

U2 - 10.1093/ofid/ofad464

DO - 10.1093/ofid/ofad464

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AN - SCOPUS:85174970945

SN - 2328-8957

VL - 10

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 10

M1 - ofad464

ER -

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated with Anti-CD20 Monoclonal Antibodies

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