Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone

Debby Ben-David; Mitchell J. Schwaber; Amos Adler; Samira Masarwa; Rotem Edgar; Shiri Navon-Venezia; David Schwartz; Nurith Porat; Tali Kotlovsky; Nikolay Polivkin; Irina Weinberg; Avraham Lazary; Nissim Ohana; Ron Dagan

doi:10.3201/eid2005.130142

Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone

Debby Ben-David
, Mitchell J. Schwaber
, Amos Adler
, Samira Masarwa
, Rotem Edgar
, Shiri Navon-Venezia
, David Schwartz
, Nurith Porat
, Tali Kotlovsky
, Nikolay Polivkin
, Irina Weinberg
, Avraham Lazary
, Nissim Ohana
, Ron Dagan

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

Original language	English
Pages (from-to)	799-805
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	20
Issue number	5
DOIs	https://doi.org/10.3201/eid2005.130142
State	Published - May 2014
Externally published	Yes

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Ben-David, D., Schwaber, M. J., Adler, A., Masarwa, S., Edgar, R., Navon-Venezia, S., Schwartz, D., Porat, N., Kotlovsky, T., Polivkin, N., Weinberg, I., Lazary, A., Ohana, N., & Dagan, R. (2014). Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone. Emerging Infectious Diseases, 20(5), 799-805. https://doi.org/10.3201/eid2005.130142

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title = "Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone",

abstract = "Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.",

author = "Debby Ben-David and Schwaber, \{Mitchell J.\} and Amos Adler and Samira Masarwa and Rotem Edgar and Shiri Navon-Venezia and David Schwartz and Nurith Porat and Tali Kotlovsky and Nikolay Polivkin and Irina Weinberg and Avraham Lazary and Nissim Ohana and Ron Dagan",

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month = may,

doi = "10.3201/eid2005.130142",

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Ben-David, D, Schwaber, MJ, Adler, A, Masarwa, S, Edgar, R, Navon-Venezia, S, Schwartz, D, Porat, N, Kotlovsky, T, Polivkin, N, Weinberg, I, Lazary, A, Ohana, N & Dagan, R 2014, 'Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone', Emerging Infectious Diseases, vol. 20, no. 5, pp. 799-805. https://doi.org/10.3201/eid2005.130142

TY - JOUR

T1 - Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone

AU - Ben-David, Debby

AU - Schwaber, Mitchell J.

AU - Adler, Amos

AU - Masarwa, Samira

AU - Edgar, Rotem

AU - Navon-Venezia, Shiri

AU - Schwartz, David

AU - Porat, Nurith

AU - Kotlovsky, Tali

AU - Polivkin, Nikolay

AU - Weinberg, Irina

AU - Lazary, Avraham

AU - Ohana, Nissim

AU - Dagan, Ron

PY - 2014/5

Y1 - 2014/5

N2 - Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

AB - Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.

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SN - 1080-6040

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SP - 799

EP - 805

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone

Abstract

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