TY - JOUR
T1 - Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae Clone
AU - Ben-David, Debby
AU - Schwaber, Mitchell J.
AU - Adler, Amos
AU - Masarwa, Samira
AU - Edgar, Rotem
AU - Navon-Venezia, Shiri
AU - Schwartz, David
AU - Porat, Nurith
AU - Kotlovsky, Tali
AU - Polivkin, Nikolay
AU - Weinberg, Irina
AU - Lazary, Avraham
AU - Ohana, Nissim
AU - Dagan, Ron
PY - 2014/5
Y1 - 2014/5
N2 - Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.
AB - Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone- resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.
UR - http://www.scopus.com/inward/record.url?scp=84898838025&partnerID=8YFLogxK
U2 - 10.3201/eid2005.130142
DO - 10.3201/eid2005.130142
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C2 - 24751142
AN - SCOPUS:84898838025
SN - 1080-6040
VL - 20
SP - 799
EP - 805
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -