Perinatal and early postnatal factors underlying developmental delay and disabilities

Zivanit Ergaz, Asher Ornoy

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A delay in meeting developmental milestones may be secondary to perinatal events, involving complicated interactions between mother and fetus during delivery. Maternal factors including weight, diet, and morbidities can affect neonatal adaptation and later development. Prematurity, low birth weight, and previous intrauterine insults as well as complications during delivery of a previously normal fetus increase the risk for perinatal stress. In this article, the literature on perinatal and early postnatal factors that underlie risks for developmental delay and disabilities is reviewed. Studies that concern neuroprotective therapies and prediction of long-term neurologic outcome by clinical examination, neuroimaging techniques, and electroencephalographic studies are reviewed as well.

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalDevelopmental Disabilities Research Reviews
Issue number2
StatePublished - Nov 2011
Externally publishedYes


  • Developmental disabilities
  • Developmental milestone delay
  • Neonatal encephalopathy
  • Neuroprotection
  • Perinatal risk factors


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