TY - JOUR
T1 - Pentagastrin-Stimulated gastric acid secretion
T2 - Does desensitization exist?
AU - Niv, Yaron
AU - Abu-Avid, Subchi
PY - 1989/12
Y1 - 1989/12
N2 - The existence of tachyphylaxis to pentagastrin-stimulated gastric acid secretion in humans is controversial. To study this, we determined gastric acid output in 19 duodenal ulcer patients following the administration of two successive intramuscular injections of pentagastrin (6 μg/kg body weight). In 18 of 19 patients, the maximal acid output decreased by 33.73 ± 3.25% (mean ± SE) following the second pentagastrin administration when compared with the maximal acid output following the first injection. This study indicates the existence of tolerance to pentagastrin-induced gastric acid secretion in humans, which may be due to a receptor-mediated phenomenon of ”down-regulation.”
AB - The existence of tachyphylaxis to pentagastrin-stimulated gastric acid secretion in humans is controversial. To study this, we determined gastric acid output in 19 duodenal ulcer patients following the administration of two successive intramuscular injections of pentagastrin (6 μg/kg body weight). In 18 of 19 patients, the maximal acid output decreased by 33.73 ± 3.25% (mean ± SE) following the second pentagastrin administration when compared with the maximal acid output following the first injection. This study indicates the existence of tolerance to pentagastrin-induced gastric acid secretion in humans, which may be due to a receptor-mediated phenomenon of ”down-regulation.”
KW - Gastric acid secretion
KW - Pentagastrin injections
KW - Receptor desensitization
UR - http://www.scopus.com/inward/record.url?scp=0024377061&partnerID=8YFLogxK
U2 - 10.1097/00004836-198912000-00007
DO - 10.1097/00004836-198912000-00007
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C2 - 2584663
AN - SCOPUS:0024377061
SN - 0192-0790
VL - 11
SP - 635
EP - 638
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
IS - 6
ER -