Penicillin-resistant pneumococcal meningitis in Israel

T. Steinberg; A. Rachmel; Z. Samra; S. Ashkenazi

Penicillin-resistant pneumococcal meningitis in Israel

T. Steinberg, A. Rachmel, Z. Samra, S. Ashkenazi

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Penicillin-resistant Streptococcus pneumoniae (PRP) is of worldwide concern. Treatment failures and fatalities of meningitis caused by PRP have been reported in other locations but not yet in Israel. We describe an 11-month-old infant with meningitis caused by PRP who failed to respond to initial treatment with cefotaxime. Vancomycin treatment caused a prompt cure. The minimal inhibitory concentrations of the isolate to penicillin, cefuroxime and cefotaxime were 1.0, 4.0 and 1.0 μg/ml, respectively. New guidelines for the treatment of meningitis in Israel are suggested.

Original language	English
Pages (from-to)	757-759
Number of pages	3
Journal	Israel Journal of Medical Sciences
Volume	33
Issue number	11
State	Published - Nov 1997
Externally published	Yes

Keywords

Meningitis
Penicillin
Pneumococci

Cite this

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title = "Penicillin-resistant pneumococcal meningitis in Israel",

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AU - Rachmel, A.

AU - Samra, Z.

AU - Ashkenazi, S.

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N2 - Penicillin-resistant Streptococcus pneumoniae (PRP) is of worldwide concern. Treatment failures and fatalities of meningitis caused by PRP have been reported in other locations but not yet in Israel. We describe an 11-month-old infant with meningitis caused by PRP who failed to respond to initial treatment with cefotaxime. Vancomycin treatment caused a prompt cure. The minimal inhibitory concentrations of the isolate to penicillin, cefuroxime and cefotaxime were 1.0, 4.0 and 1.0 μg/ml, respectively. New guidelines for the treatment of meningitis in Israel are suggested.

AB - Penicillin-resistant Streptococcus pneumoniae (PRP) is of worldwide concern. Treatment failures and fatalities of meningitis caused by PRP have been reported in other locations but not yet in Israel. We describe an 11-month-old infant with meningitis caused by PRP who failed to respond to initial treatment with cefotaxime. Vancomycin treatment caused a prompt cure. The minimal inhibitory concentrations of the isolate to penicillin, cefuroxime and cefotaxime were 1.0, 4.0 and 1.0 μg/ml, respectively. New guidelines for the treatment of meningitis in Israel are suggested.

KW - Meningitis

KW - Penicillin

KW - Pneumococci

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JO - Israel Journal of Medical Sciences

JF - Israel Journal of Medical Sciences

IS - 11

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Penicillin-resistant pneumococcal meningitis in Israel

Abstract

Keywords

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