P-glycoprotein-mediated renal tubular secretion of digoxin: The toxicological significance of the urine-blood barrier model

Shinya Ito, Cindy Woodland, Patricia A. Harper, Gideon Koren

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycoprotein mediates digoxin secretion in the renal tubular cells. Based on existing data on digoxin transport, we present a hypothetical model for the renal handling of digoxin, implying that P-glycoprotein functions as a driving mechanism of a unidirectional "urine-blood" barrier.

Original languageEnglish
Pages (from-to)PL25-PL31
JournalLife Sciences
Volume53
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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