Abstract
We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycoprotein mediates digoxin secretion in the renal tubular cells. Based on existing data on digoxin transport, we present a hypothetical model for the renal handling of digoxin, implying that P-glycoprotein functions as a driving mechanism of a unidirectional "urine-blood" barrier.
Original language | English |
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Pages (from-to) | PL25-PL31 |
Journal | Life Sciences |
Volume | 53 |
Issue number | 2 |
DOIs | |
State | Published - 1993 |
Externally published | Yes |