Abstract
TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 4367-4369 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 49 |
| Issue number | 39 |
| DOIs | |
| State | Published - 18 Apr 2013 |
| Externally published | Yes |