Organocatalytic oxidation of aldehydes to mixed anhydrides

Hila Toledo, Evgeni Pisarevsky, Adi Abramovich, Alex M. Szpilman

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.

Original languageEnglish
Pages (from-to)4367-4369
Number of pages3
JournalChemical Communications
Issue number39
StatePublished - 18 Apr 2013
Externally publishedYes


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