Optimizing the average distance between a blue light photosensitizer and a harmonic nanoparticle for effective infrared photodynamic therapy

Ayan Barbora, Svetlana Lyssenko, Michal Amar, Vadim Nave, Vered Zivan, Lital Argaev Frenkel, Ariel Nause, Raichel Cohen-Harazi, Refael Minnes

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Photodynamic therapy can be significantly improved by techniques utilizing light windows of higher tissue penetration depths with optimally matched photoactive agents to provide deep interstitial treatment. Classical blue light photosensitizers were photodynamically activated using infrared light via coupled harmonic nanoparticles with optimized intermediary distances using spacers. Upon 800 nm pulsed laser irradiation perovskite nanoparticles with optimized coupling to either curcumin or protoporphyrin IX reduced the viability of MCF7 breast cancer cells by 73 percent and 64 percent, respectively, while exhibiting negligible dark toxicity. The findings pave the way for clinical adaptation of ease-of-synthesis photodynamically active preparations operable under deep tissue penetrating infrared lights using commonly available otherwise infrared inactive classical blue light photosensitizers.

Original languageEnglish
Article number123195
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume303
DOIs
StatePublished - 15 Dec 2023

Keywords

  • Near Infrared Laser
  • Perovskite
  • Photodynamic Therapy
  • Photosensitizer
  • Second Harmonic Nanoparticles

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