Optical imaging characterizing brain response to thermal insult in injured rodent

David Abookasis, Oren Shaul, Omri Meitav, Gadi A. Pinhasi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


We used spatially modulated optical imaging system to assess the effect of temperature elevation on intact brain tissue in a mouse heatstress model. Heatstress or heatstroke is a medical emergency defined by abnormally elevated body temperature that causes biochemical, physiological and hematological changes. During experiments, brain temperature was measured concurrently with a thermal camera while core body temperature was monitored with rectal thermocouple probe. Changes in a battery of macroscopic brain physiological parameters, such as hemoglobin oxygen saturation level, cerebral water content, as well as intrinsic tissue optical properties were monitored during temperature elevation. These concurrent changes reflect the pathophysiology of the brain during heatstress and demonstrate successful monitoring of thermoregulation mechanisms. In addition, the variation of tissue refractive index was calculated showing a monotonous decrease with increasing wavelength. We found increased temperature to greatly affect both the scattering properties and refractive index which represent cellular and subcellular swelling indicative of neuronal damage. The overall trends detected in brain tissue parameters were consistent with previous observations using conventional medical devices and optical modalities.

Original languageEnglish
Title of host publicationClinical and Translational Neurophotonics 2018
EditorsVictor X. D. Yang, Steen J. Madsen
ISBN (Electronic)9781510614451
StatePublished - 2018
EventClinical and Translational Neurophotonics 2018 - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceClinical and Translational Neurophotonics 2018
Country/TerritoryUnited States
CitySan Francisco


  • Absorption and scattering properties
  • Cerebral hemodynamics
  • Heatstress
  • Refractive index
  • Spatially modulated NIR imaging


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