Opsin shift in an aldolase antibody

Flavio Grynszpan, Ehud Keinan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An antibody-retinal assembly that mimics the opsin shift (OS) of the naturally occurring visual pigments is reported. Both experiments and calculations show that the aldolase antibody 33F12 covalently binds all-trans retinal via a protonated Schiff base with a lysine residue. This chromophore, which exhibits a remarkable opsin red shift (140 nm), represents a useful model system for studying the factors that contribute to the OS.

Original languageEnglish
Pages (from-to)2419-2424
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number16
DOIs
StatePublished - 16 Aug 1999
Externally publishedYes

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