One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

Gary Gellerman; Vladimir Gaisin; Tamara Brider

doi:10.1016/j.tetlet.2009.12.020

One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and S_NAr reaction

Gary Gellerman
, Vladimir Gaisin
, Tamara Brider

Department of Chemical Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and S_NAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

Original language	English
Pages (from-to)	836-839
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	5
DOIs	https://doi.org/10.1016/j.tetlet.2009.12.020
State	Published - 3 Feb 2010

Keywords

9-Aminoacridine
Nucleophilic substitution
One-pot synthesis
Reductive alkylation

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10.1016/j.tetlet.2009.12.020

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title = "One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction",

abstract = "A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.",

keywords = "9-Aminoacridine, Nucleophilic substitution, One-pot synthesis, Reductive alkylation",

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AU - Gellerman, Gary

AU - Gaisin, Vladimir

AU - Brider, Tamara

PY - 2010/2/3

Y1 - 2010/2/3

N2 - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

AB - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

KW - 9-Aminoacridine

KW - Nucleophilic substitution

KW - One-pot synthesis

KW - Reductive alkylation

UR - https://www.scopus.com/pages/publications/73049084566

U2 - 10.1016/j.tetlet.2009.12.020

DO - 10.1016/j.tetlet.2009.12.020

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SN - 0040-4039

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

ER -

One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and S_NAr reaction

Abstract

Keywords

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