Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells

Biochemistry, Genetics and Molecular Biology

• Oncogene 100%
• DNA Damage Response 100%
• Isoform 50%
• Downregulation 50%
• Upregulation 50%
• Transgenic Mouse 50%
• Morphology 50%
• P21 50%
• Mouse Model 50%
• Kinase 50%
• Phosphotransferase 50%
• Cyclin-Dependent Kinase 50%
• Mouse Mammary Tumor Virus 50%
• Oncogene Ras 50%
• Erethism 50%
• Histone 50%
• Double-Strand DNA Break 50%
• Galactosidase 50%

Keyphrases

• Oncogene 100%
• Senescence 100%
• DNA Damage Response 100%
• Growth Arrest 100%
• Immortalized Cell 100%
• Incomplete Growth 100%
• Senescence-associated 33%
• Human Epidermal Growth Factor Receptor 2 (HER2) 22%
• Morphological Changes 11%
• Breast 11%
• Tumor 11%
• Cancer Development 11%
• Rodents 11%
• β-Galactosidase (β-Gal) 11%
• Breast Epithelial Cells 11%
• DNA Instability 11%
• DNA Double-strand Breaks 11%
• Histone H2AX 11%
• ErbB2 11%
• Genotoxic Stress 11%
• CHK1 Kinase 11%
• RAS Oncogene 11%
• Cyclin-dependent Kinase Inhibitor p21 11%
• Transgenic Mouse Model 11%
• Tumor Xenograft 11%
• Associated Phenotypes 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Growth Disorder 100%
• Dicarbonate 33%
• Neoplasm 22%
• Malignant Neoplasm 11%
• Transgenic Mouse 11%
• Phosphotransferase 11%
• Mouse Model 11%
• Cyclin Dependent Kinase Inhibitor 1A 11%
• Galactosidase 11%
• Double Stranded DNA 11%
• Erethism 11%
• Histone H2AX 11%
• Mouse Mammary Tumor Virus 11%