@article{230aaae5d6874e509452713f8dd4d5f6,
title = "Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases",
abstract = "Chronic use of chloroquine and hydroxychloroquine in the treatment of rheumatic disease carries a small risk of sight-threatening pigmentary retinopathy. To obtain safety data for its use in pregnancy, we did ophthalmic examinations in 21 children born to women who took these drugs during pregnancy. Average daily maternal doses of the two drugs were 317 mg hydroxychloroquine and 332 mg chloroquine. The mean duration of gestational exposure was 7.2 months. No ophthalmic abnormality was detected in these children. Therapeutic use of these drugs during pregnancy may not pose a significant risk of ocular toxicity to offspring.",
author = "Gil Klinger and Yair Morad and Westall, {Carol A.} and Carl Laskin and Spitzer, {Karen A.} and Gideon Koren and Shinya Ito and Buncic, {Raymond J.}",
note = "Funding Information: G Klinger received a fellowship award from the Research Institute, Hospital for Sick Children, Toronto, Canada. G Koren was supported by Senior Scientists Award from the Canadian Institute of Health Research. S Ito was supported by Career Award in Health Sciences from the Canadian Institute of Health Research and the Health Research Foundation. This study was supported in part by the Motherisk Research fund, and by Breastfeeding Programme fund, Hospital for Sick Children, Toronto.",
year = "2001",
month = sep,
day = "8",
doi = "10.1016/S0140-6736(01)06004-4",
language = "אנגלית",
volume = "358",
pages = "813--814",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier B.V.",
number = "9284",
}