Occurrence of BNT162b2 vaccine adverse reactions is associated with enhanced SARS-CoV-2 IgG antibody response

Yoav Rechavi, Moshe Shashar, Jonathan Lellouche, Moshe Yana, Daniel Yakubovich, Nechama Sharon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Promoting SARS-CoV-2 vaccination has been a global mission since the first vaccines were approved for emergency use. Alongside the excitement following the possibility of eradicating SARS-CoV-2 and ending the COVID-19 pandemic, there has been ample vaccine hesitancy, some due to the abundant reporting of adverse reactions. We report here that the occurrence of BNT162b2 vaccine adverse reactions is associated with enhanced antibody response. We found a statistically significant correlation between having an adverse reaction, whether local or systemic, and higher antibody levels. No sex difference was observed in antibody levels. However, as was recently reported, the antibody response was found to be lower among older vaccinees. The demonstration of a clear correlation between adverse reactions and antibody levels may help reduce vaccination hesitancy by reassuring that the presence of such reactions is an indication of a well-functioning immune system.

Original languageEnglish
Article number977
JournalVaccines
Volume9
Issue number9
DOIs
StatePublished - Sep 2021
Externally publishedYes

Keywords

  • Adverse reactions
  • Antibodies
  • BNT162b2
  • COVID-19
  • SARS-CoV-2
  • Vaccination hesitancy
  • Vaccine

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