Non-ionizing millimeter waves non-thermal radiation of saccharomyces cerevisiae—Insights and interactions

Ayan Barbora, Shailendra Rajput, Konstantin Komoshvili, Jacob Levitan, Asher Yahalom, Stella Liberman-Aronov

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Non-ionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85–105 GHz MMW irradiation within the International Commission on Non-Ionizing Radiation Protection (ICNIRP) non-thermal 20 mW/cm2 safety standards. Irradiation using a power density of about 1.0 mW/cm2 SAR over 5–6 h on 50 cells/µL samples of Saccharomyces cerevisiae model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85–105 GHz range and was energy-and cell density-dependent. Irradiation of wild type and ∆rad52 (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm2) and compared to that of a compact waveguide (17.17 mW/cm2) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes.

Original languageEnglish
Article number6635
JournalApplied Sciences (Switzerland)
Volume11
Issue number14
DOIs
StatePublished - 2 Jul 2021

Keywords

  • Millimeter waves
  • Non-invasive devices
  • Non-ionizing radiation
  • Novel biomedical applications
  • Yeast

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