TY - JOUR
T1 - Non-coding RNAs in normal B-cell development and in mantle cell lymphoma
T2 - From molecular mechanism to biomarker and therapeutic agent potential
AU - Kersy, Olga
AU - Salmon-Divon, Mali
AU - Shpilberg, Ofer
AU - Hershkovitz-Rokah, Oshrat
N1 - Publisher Copyright:
© 2021 by the author. Licensee MDPI, Basel, Switzerland.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - B-lymphocytes are essential for an efficient immune response against a variety of path-ogens. A large fraction of hematologic malignancies are of B-cell origin, suggesting that the development and activation of B cells must be tightly regulated. In recent years, differentially expressed non-coding RNAs have been identified in mantle cell lymphoma (MCL) tumor samples as opposed to their naive, normal B-cell compartment. These aberrantly expressed molecules, specif-ically microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), have a role in cellular growth and survival pathways in various biological models. Here, we pro-vide an overview of current knowledge on the role of non-coding RNAs and their relevant targets in B-cell development, activation and malignant transformation, summarizing the current understanding of the role of aberrant expression of non-coding RNAs in MCL pathobiology with per-spectives for clinical use.
AB - B-lymphocytes are essential for an efficient immune response against a variety of path-ogens. A large fraction of hematologic malignancies are of B-cell origin, suggesting that the development and activation of B cells must be tightly regulated. In recent years, differentially expressed non-coding RNAs have been identified in mantle cell lymphoma (MCL) tumor samples as opposed to their naive, normal B-cell compartment. These aberrantly expressed molecules, specif-ically microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), have a role in cellular growth and survival pathways in various biological models. Here, we pro-vide an overview of current knowledge on the role of non-coding RNAs and their relevant targets in B-cell development, activation and malignant transformation, summarizing the current understanding of the role of aberrant expression of non-coding RNAs in MCL pathobiology with per-spectives for clinical use.
KW - B-cell lymphoma
KW - CircRNA
KW - LncRNA
KW - Mantle cell lymphoma
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=85114034934&partnerID=8YFLogxK
U2 - 10.3390/ijms22179490
DO - 10.3390/ijms22179490
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C2 - 34502399
AN - SCOPUS:85114034934
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 17
M1 - 9490
ER -