New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections.

Faina Nakonechny; Marina Nisnevitch; Yeshayahu Nitzan; Michael Firer

New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections.

Faina Nakonechny, Marina Nisnevitch, Yeshayahu Nitzan, Michael Firer

Department of Chemical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promote
alternate technologies that may be more affective than current antibiotics. This article reviews Photodynamic
Antimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visible
light illumination and found to be effective against most types of microbial pathogens, including those
resistant to antibiotics. PACT nonetheless has certain limitations, particularly against internal and blood-borne
infections. To this end, we are developing Chemiluminescent Photodynamic Antimicrobial Therapy (CPAT).
This review also summarizes our recent data on CPAT. The practical advantages of CPAT emphasize that this
novel technique could expand efforts to control nosocomial pathogens, including those responsible for
systemic infections.

Original language	English
Title of host publication	Science against microbial pathogens: communicating current research and technological advances
Editors	A Mendez-Vilas
Place of Publication	Spain
Pages	684-691
Number of pages	8
State	Published - 2011

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Nakonechny, F., Nisnevitch, M., Nitzan, Y., & Firer, M. (2011). New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections. In A. Mendez-Vilas (Ed.), Science against microbial pathogens: communicating current research and technological advances (pp. 684-691). https://www.researchgate.net/publication/233740639_New_techniques_in_antimicrobial_photodynamic_therapy_scope_of_application_and_overcoming_drug_resistance_in_nosocomial_infections

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title = "New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections.",

abstract = "Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promotealternate technologies that may be more affective than current antibiotics. This article reviews PhotodynamicAntimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visiblelight illumination and found to be effective against most types of microbial pathogens, including thoseresistant to antibiotics. PACT nonetheless has certain limitations, particularly against internal and blood-borneinfections. To this end, we are developing Chemiluminescent Photodynamic Antimicrobial Therapy (CPAT).This review also summarizes our recent data on CPAT. The practical advantages of CPAT emphasize that thisnovel technique could expand efforts to control nosocomial pathogens, including those responsible forsystemic infections.",

author = "Faina Nakonechny and Marina Nisnevitch and Yeshayahu Nitzan and Michael Firer",

year = "2011",

language = "English",

isbn = "9788493984311",

pages = "684--691",

editor = "A Mendez-Vilas",

booktitle = "Science against microbial pathogens: communicating current research and technological advances",

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Nakonechny, F , Nisnevitch, M, Nitzan, Y & Firer, M 2011, New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections. in A Mendez-Vilas (ed.), Science against microbial pathogens: communicating current research and technological advances. Spain, pp. 684-691. <https://www.researchgate.net/publication/233740639_New_techniques_in_antimicrobial_photodynamic_therapy_scope_of_application_and_overcoming_drug_resistance_in_nosocomial_infections>

New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections. / Nakonechny, Faina ; Nisnevitch, Marina; Nitzan, Yeshayahu et al.
Science against microbial pathogens: communicating current research and technological advances. ed. / A Mendez-Vilas. Spain, 2011. p. 684-691.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections.

AU - Nakonechny, Faina

AU - Nisnevitch, Marina

AU - Nitzan, Yeshayahu

AU - Firer, Michael

PY - 2011

Y1 - 2011

N2 - Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promotealternate technologies that may be more affective than current antibiotics. This article reviews PhotodynamicAntimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visiblelight illumination and found to be effective against most types of microbial pathogens, including thoseresistant to antibiotics. PACT nonetheless has certain limitations, particularly against internal and blood-borneinfections. To this end, we are developing Chemiluminescent Photodynamic Antimicrobial Therapy (CPAT).This review also summarizes our recent data on CPAT. The practical advantages of CPAT emphasize that thisnovel technique could expand efforts to control nosocomial pathogens, including those responsible forsystemic infections.

AB - Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promotealternate technologies that may be more affective than current antibiotics. This article reviews PhotodynamicAntimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visiblelight illumination and found to be effective against most types of microbial pathogens, including thoseresistant to antibiotics. PACT nonetheless has certain limitations, particularly against internal and blood-borneinfections. To this end, we are developing Chemiluminescent Photodynamic Antimicrobial Therapy (CPAT).This review also summarizes our recent data on CPAT. The practical advantages of CPAT emphasize that thisnovel technique could expand efforts to control nosocomial pathogens, including those responsible forsystemic infections.

M3 - Chapter

SN - 9788493984311

SP - 684

EP - 691

BT - Science against microbial pathogens: communicating current research and technological advances

A2 - Mendez-Vilas, A

CY - Spain

ER -

New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections.

Abstract

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