TY - JOUR
T1 - Neuroblastoma after prenatal exposure to phenytoin
T2 - Cause and effect?
AU - Koren, Gideon
AU - Demitrakoudis, Demitri
AU - Weksberg, Rosanna
AU - Rieder, Michael
AU - Shear, Neil H.
AU - Sonely, Marylin
AU - Shandling, Barry
AU - Spielberg, Stephen P.
PY - 1989/8
Y1 - 1989/8
N2 - We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin‐induced reactions in an unusual sibship. In addition, we investigated intrauterine phenytoin exposure in a case series of infants and children with neuroblastoma diagnosed over 17 years at our center. The response of lymphocytes from our index case with neuroblastoma exposed in utero to phenytoin was within the normal range, whereas the mother and a sibling with fetal hydantoin syndrome (FHS) exhibited an intermediate toxicity. None of the 188 case of childhood neuroblastoma diagnosed between 1969 and 1988 had been exposed in utero to phenytoin, indicating that, statistically, the drug cannot be associated with neuroblastoma in more than two cases with this malignancy in our cohort, or in 1.5% of all cases of neuroblastoma. Although our data do not suggest an association between phenytoin in pregnancy and postnatal neuroblastoma, it is still possible that there is an increased risk for neuroblastoma in children with FHS.
AB - We evaluated the causality of the association between intrauterine exposure to phenytoin and postnatal neuroblastoma using an in vitro lymphocyte toxicity assay for phenytoin‐induced reactions in an unusual sibship. In addition, we investigated intrauterine phenytoin exposure in a case series of infants and children with neuroblastoma diagnosed over 17 years at our center. The response of lymphocytes from our index case with neuroblastoma exposed in utero to phenytoin was within the normal range, whereas the mother and a sibling with fetal hydantoin syndrome (FHS) exhibited an intermediate toxicity. None of the 188 case of childhood neuroblastoma diagnosed between 1969 and 1988 had been exposed in utero to phenytoin, indicating that, statistically, the drug cannot be associated with neuroblastoma in more than two cases with this malignancy in our cohort, or in 1.5% of all cases of neuroblastoma. Although our data do not suggest an association between phenytoin in pregnancy and postnatal neuroblastoma, it is still possible that there is an increased risk for neuroblastoma in children with FHS.
UR - http://www.scopus.com/inward/record.url?scp=0024452011&partnerID=8YFLogxK
U2 - 10.1002/tera.1420400209
DO - 10.1002/tera.1420400209
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C2 - 2672404
AN - SCOPUS:0024452011
SN - 0040-3709
VL - 40
SP - 157
EP - 162
JO - Teratology
JF - Teratology
IS - 2
ER -