Nanoparticles as computed tomography contrast agents: Current status and future perspectives

Malka Shilo, Tobi Reuveni, Menachem Motiei, Rachela Popovtzer

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


The importance of computed tomography (CT) as one of the leading radiology technologies applied in the field of biomedical imaging escalated the development of nanoparticles as the next generation CT contrast agents. Nanoparticles are expected to play a major role in the future of medical diagnostics due to their many advantages over the conventional contrast agents, such as prolonged blood circulation time, controlled biological clearance pathways and specific molecular targeting capabilities. This paper will describe the basic design principles of nanoparticle-based CT contrast agents and review the state-of-the-art developments and clinical applications of blood pool, passive and active targeting CT contrast agents.

Original languageEnglish
Pages (from-to)257-269
Number of pages13
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • active targeting
  • atherosclerosis
  • blood pool contrast agents
  • cancer
  • computed tomography
  • in vivo imaging
  • molecular imaging
  • nanoparticles
  • passive targeting


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