N-Acetylcysteine for the Treatment of Clove Oil-Induced Fulminant Hepatic Failure

Jeffrey S. Eisen, Gideon Koren, David N. Juurlink, Vicky L. Ng

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


We present a 3-month-old female who developed fulminant hepatic failure after ingesting less than 8 mL of clove oil. Initial treatment involved gastrointestinal decontamination, supportive measures, and admission to hospital. She subsequently developed fulminant hepatic failure and was treated with intravenous N-acetylcysteine (N-AC) according to a protocol used for acetaminophen poisoning. Over the next 72h her liver synthetic function and clinical status improved, and she made a complete recovery. Previous reported cases of clove oil toxicity and the potential role of N-AC therapy are reviewed.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalJournal of Toxicology - Clinical Toxicology
Issue number1
StatePublished - 2004
Externally publishedYes


  • Acetylcysteine
  • Eugenol
  • Liver failure
  • Poisoning


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