TY - JOUR
T1 - Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents
T2 - Hapten design and synthesis
AU - Huang, H.
AU - Han, W. G.
AU - Noodleman, L.
AU - Grynszpan, F.
N1 - Funding Information:
We are grateful to Schrödinger, Inc. for a temporary license of Jaguar. F.G. thanks the J. S. Guggenheim Memorial Foundation for a fellowship. We thank Professor R. A. Lerner for financial support and insightful discussion. We thank Professor E. J. Baerends and the Theoretical Chemistry group at the Free University of Amsterdam for use of the ADF code.
PY - 2001/12
Y1 - 2001/12
N2 - We designed and synthesized a series of haptens to elicit catalytic antibodies with phosphatase activity against nerve agents. The design is based on the novel concept of multiple reactive immunization which aims to afford two or more catalytic residues within the antibody's binding cleft. The haptens showed the desired reactivity in vitro and were submitted for immunization.
AB - We designed and synthesized a series of haptens to elicit catalytic antibodies with phosphatase activity against nerve agents. The design is based on the novel concept of multiple reactive immunization which aims to afford two or more catalytic residues within the antibody's binding cleft. The haptens showed the desired reactivity in vitro and were submitted for immunization.
UR - http://www.scopus.com/inward/record.url?scp=0035169568&partnerID=8YFLogxK
U2 - 10.1016/S0968-0896(01)00231-0
DO - 10.1016/S0968-0896(01)00231-0
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C2 - 11711294
AN - SCOPUS:0035169568
SN - 0968-0896
VL - 9
SP - 3185
EP - 3195
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 12
ER -