Multiple Hematopoietic-Cell Lineages in Multiple Myeloma

Ofer Shpilberg, Michaela Modan, Baruch Modan, Bracha Ramot, Joshua Epstein, Huiqing Xiao, Xiao Yan he

Research output: Contribution to journalLetterpeer-review


To the Editor: Using flow cytometry, Epstein and colleagues (March 8 issue)* found that myeloma cells expressed not only features characteristic of myeloma cells but also markers expressed on preB cells, megakaryocytes, myelomonocytes, and erythroid cells. The authors concluded that cells of multiple lineages are involved in multiple myeloma, and mentioned that these findings could imply the existence of a common neoplastic progenitor for all hematologic tumors. Another way to investigate the level at which the malignant process occurs in hematologic cancers is by determining the familial aggregation of hematologic cancers among patients with a specific disease — i.e., multiple…

Original languageEnglish
Pages (from-to)277
Number of pages1
JournalNew England Journal of Medicine
Issue number4
StatePublished - 26 Jul 1990
Externally publishedYes


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