MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Jeff W.M. Bulte; Tamir Ben-Hur; Bradley R. Miller; Rachel Mizrachi-Kol; Ophira Einstein; Etti Reinhartz; Holly A. Zywicke; Trevor Douglas; Joseph A. Frank

doi:10.1002/mrm.10511

MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Jeff W.M. Bulte, Tamir Ben-Hur, Bradley R. Miller, Rachel Mizrachi-Kol, Ophira Einstein, Etti Reinhartz, Holly A. Zywicke, Trevor Douglas, Joseph A. Frank

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Magnetic Resonance in Medicine
Volume	50
Issue number	1
DOIs	https://doi.org/10.1002/mrm.10511
State	Published - 1 Jul 2003
Externally published	Yes

Keywords

Experimental autoimmune encephalomyelitis
Iron oxide MR contrast agent
MR microscopy
Neurospheres
Transplantation

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10.1002/mrm.10511

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abstract = "Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.",

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AU - Einstein, Ophira

AU - Reinhartz, Etti

AU - Zywicke, Holly A.

AU - Douglas, Trevor

AU - Frank, Joseph A.

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AB - Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.

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KW - Neurospheres

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MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

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Keywords

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