Motherisk update: Trimethoprim-sulfonamide combination therapy in early pregnancy

Anna Sivojelezova, Adrienne Einarson, Samar Shuhaiber, Gideon Koren

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Question. One of my patients presented with bacteriuria early in her pregnancy. Urine culture was positive for Escherichia coli. I would like to prescribe a trimethoprim-sulfamethoxazole combination because it worked for her in the past. What is known about the safety of this medicatioon during early pregnancy? Answer. Evidence-based studies report and association between trimethoprim-sulfonamide combinations in early pregnancy and several major malformations, such as neural tube defects and cardiovascular defects. If clinically possible, physicians are advised to use alternative antimicrobial medications for treatment of urinary infections during early pregnancy.

Original languageEnglish
Pages (from-to)1085-1086
Number of pages2
JournalCanadian Family Physician
Issue numberSEPT.
StatePublished - 1 Sep 2003
Externally publishedYes


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