Motherisk update: Effect to methotrexate on male fertility

Amy E. French, Gideon Koren

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Question. Several men with psoriatic arthritis have asked wether the methotrexate they take for rheumatoid arthritis will affect their fertility or the outcome of any of their partner's future pregnancies. What is known regarding risks to fertility and to retuses? Answer. To date, there are no reports of adverse pregnancy outcomes among men exposed to methotrexate before conception. Opinions in the literature differ on the effects of methotrexate on male fertility. Several case reports and studies report no effect; others report reversible sterility. One limitation to several on these studies in the concurrent administration of other chemotherapeutic agents. Small studies reporting on methotrexate use with no other agents suggest no increased infertility. Motherisk is currently following when who are taking methotrexate alone for psoriatic arthritis to see whether it affects fertility.

Original languageEnglish
Pages (from-to)577-578
Number of pages2
JournalCanadian Family Physician
Issue numberMAY
StatePublished - 1 May 2003
Externally publishedYes


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