Motherisk Rounds: The Fetal Safety of Benzodiazepines: An Updated Meta-analysis

Ehijie Enato; Myla Moretti; Gideon Koren

doi:10.1016/S1701-2163(16)34772-7

Motherisk Rounds: The Fetal Safety of Benzodiazepines: An Updated Meta-analysis

Ehijie Enato
, Myla Moretti
, Gideon Koren

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.

Original language	English
Pages (from-to)	46-48
Number of pages	3
Journal	Journal of Obstetrics and Gynaecology Canada
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/S1701-2163(16)34772-7
State	Published - 2011
Externally published	Yes

Keywords

Benzodiazepine
Malformation risk
Teratogenicity

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10.1016/S1701-2163(16)34772-7

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abstract = "Benzodiazepines are commonly used by women of reproductive age, and hence many pregnant women are exposed to them. An updated meta-analysis of their fetal safety synthesized nine studies with over one million pregnancies, yielding an odds ratio of 1.07 (95\% CI 0.91 to 1.25). While benzodiazepines do not appear to increase teratogenic risk in general, case-controls suggest a twofold increased risk of oral cleft.",

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Motherisk Rounds: The Fetal Safety of Benzodiazepines: An Updated Meta-analysis

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Keywords

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