TY - GEN
T1 - Monitoring optical and physiologic properties of brain in response to anesthetic drugs using hybrid optical imaging system
AU - Abookasis, David
AU - Cohen, Elkana David
N1 - Publisher Copyright:
© 2025 SPIE.
PY - 2025
Y1 - 2025
N2 - Optical imaging setup based on the combination of spatially modulated visible light illumination and laser speckle technique is utilized to evaluate the effect of anesthetic drugs on several brain parameters including absorption, scattering, oxygen saturation, cerebral blood flow and more. Two anesthetic drugs ketamine-xylazine (KX) and thiopental were investigated. During experiments, a series of visible sinusoidal patterns with different spatial frequencies are projected onto a mouse brain and diffusely reflected light is recorded by a camera. Then, illumination is blocked, and a laser light shines on the brain while the diffusely reflected light is recorded by the same camera. In this manner, visible and laser speckle images are captured and processed to reconstruct the cerebral tissue features. Variations in optical properties, levels of tissue chromophore content, and in blood flow were observed.
AB - Optical imaging setup based on the combination of spatially modulated visible light illumination and laser speckle technique is utilized to evaluate the effect of anesthetic drugs on several brain parameters including absorption, scattering, oxygen saturation, cerebral blood flow and more. Two anesthetic drugs ketamine-xylazine (KX) and thiopental were investigated. During experiments, a series of visible sinusoidal patterns with different spatial frequencies are projected onto a mouse brain and diffusely reflected light is recorded by a camera. Then, illumination is blocked, and a laser light shines on the brain while the diffusely reflected light is recorded by the same camera. In this manner, visible and laser speckle images are captured and processed to reconstruct the cerebral tissue features. Variations in optical properties, levels of tissue chromophore content, and in blood flow were observed.
KW - Anesthetics drugs
KW - Laser speckle imaging
KW - Optical and physiologic properties
KW - Spatially modulated visible light
UR - http://www.scopus.com/inward/record.url?scp=105004272806&partnerID=8YFLogxK
U2 - 10.1117/12.3041189
DO - 10.1117/12.3041189
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AN - SCOPUS:105004272806
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Clinical and Translational Neurophotonics 2025
A2 - Kainerstorfer, Jana M.
A2 - Buckley, Erin M.
A2 - Buckley, Erin M.
A2 - Srinivasan, Vivek Jay
PB - SPIE
T2 - Clinical and Translational Neurophotonics 2025
Y2 - 25 January 2025 through 27 January 2025
ER -