TY - JOUR
T1 - Molecular epidemiology of hematological neoplasms - present status and future directions
AU - Shpilberg, Ofer
AU - Dorman, Janice S.
AU - Shahar, Avner
AU - Kuller, Lewis H.
N1 - Funding Information:
Building of informative, representative, and reliable biological registries that were made available through family and case-control studies in HN that will enable the testing of innovative hypotheses on the molecular mechanisms involved in the developmento f HN. This can be achieved by routine storage of peripheralb lood and bone marrow specimensa s part of a routine medical practice, and must be funded from research grants. With the rapid developments in molecular diagnosis of HN, existing patients may still benefit directly from future analyses of their stored samples.
PY - 1997/4
Y1 - 1997/4
N2 - The field of molecular epidemiology, using modern epidemiological approaches and taking the advantage of the advances in molecular biology can provide new tools for the exploration of etiological determinants, either environmental or hereditary, in the development of hematological neoplasms. It is now possible to identify some host susceptibility characteristics, to measure the effective dose of exposure, and to identify early, pre-clinical biological effects, using sensitive and specific biomarkers. The significant variation in the incidence of hematological neoplasms in different geographical areas, races, and age groups, the high rates of familiar aggregation in certain populations, the involvement of proto-oncogenes and tumor suppressor genes in the development of hematological neoplasms, as well as of many environmental agents such as chemicals, radiation, and viruses, support the important role of molecular epidemiology in the investigation of the development of hematological neoplasms.
AB - The field of molecular epidemiology, using modern epidemiological approaches and taking the advantage of the advances in molecular biology can provide new tools for the exploration of etiological determinants, either environmental or hereditary, in the development of hematological neoplasms. It is now possible to identify some host susceptibility characteristics, to measure the effective dose of exposure, and to identify early, pre-clinical biological effects, using sensitive and specific biomarkers. The significant variation in the incidence of hematological neoplasms in different geographical areas, races, and age groups, the high rates of familiar aggregation in certain populations, the involvement of proto-oncogenes and tumor suppressor genes in the development of hematological neoplasms, as well as of many environmental agents such as chemicals, radiation, and viruses, support the important role of molecular epidemiology in the investigation of the development of hematological neoplasms.
KW - Environmental exposure
KW - Genetic predisposition
KW - Hematologic neoplasms
KW - Molecular epidemiology
UR - http://www.scopus.com/inward/record.url?scp=0030951136&partnerID=8YFLogxK
U2 - 10.1016/S0145-2126(96)00093-8
DO - 10.1016/S0145-2126(96)00093-8
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C2 - 9150344
AN - SCOPUS:0030951136
SN - 0145-2126
VL - 21
SP - 265
EP - 284
JO - Leukemia Research
JF - Leukemia Research
IS - 4
ER -