TY - JOUR
T1 - Models of acetylation and the regulation of longevity
T2 - From yeast to humans
AU - Finkel, Moran
AU - Cohen, Haim
N1 - Funding Information:
We thank members of the Cohen's lab for editorial comments and apologize for those whose work was not cited owing to space limitations. The work in the Cohen's lab was supported by the Koret, Alon and the German–Israeli foundations.
PY - 2005
Y1 - 2005
N2 - In recent years it has emerged that acetylation, and especially the activity of certain deacetylases, regulates lifespan in model organisms. Among the three classes of deacetylases, the role of class III, sirtuins NAD+-dependent deacetylases, in regulating aging is the best studied. Sirtuins are conserved from bacteria to human and overexpression of sirtuins in yeast, nematodes and flies extends their lifespan, implying a conserved fundamental mechanism by which sirtuins regulate aging. In this review we will focus on the role of deacetylases, especially sirtuins, in regulating longevity and will describe and discuss their role in regulating lifespan from yeast to human.
AB - In recent years it has emerged that acetylation, and especially the activity of certain deacetylases, regulates lifespan in model organisms. Among the three classes of deacetylases, the role of class III, sirtuins NAD+-dependent deacetylases, in regulating aging is the best studied. Sirtuins are conserved from bacteria to human and overexpression of sirtuins in yeast, nematodes and flies extends their lifespan, implying a conserved fundamental mechanism by which sirtuins regulate aging. In this review we will focus on the role of deacetylases, especially sirtuins, in regulating longevity and will describe and discuss their role in regulating lifespan from yeast to human.
UR - http://www.scopus.com/inward/record.url?scp=30444451474&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2005.11.003
DO - 10.1016/j.ddmod.2005.11.003
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AN - SCOPUS:30444451474
SN - 1740-6757
VL - 2
SP - 265
EP - 271
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 4
ER -