TY - GEN
T1 - Modeling the influence of molecule and cell surface micro-domain distribution on the formation of T cell immunological synapses
AU - Kotzer, Shulamit
AU - Salmon-Divon, Mali
AU - Kaplan, Asya
AU - Almeida, Catarina R.
AU - Höglund, Petter
AU - Davis, Daniel M.
AU - Mehr, Ramit
PY - 2007
Y1 - 2007
N2 - Proper functioning of the immune system depends on coordinated intercellular communication that occurs in the "immunological synapse". This is the contact area of cell-cell conjugates where information is transferred via segregated clusters of proteins. Vast experimental datasets on its assembly are available, and mathematical and computational modeling represent a useful tool to integrate all this information. We created a stochastic computer simulation to study immunological synapse formation. Using this simulation we show that the initial locations of adhesion molecules and T cell receptors (TCRs) at the moment of contact influence the inversion of the immature synapse into a mature synapse, and that movement of large clusters of TCRs towards the center of the contact area accelerates this inversion.
AB - Proper functioning of the immune system depends on coordinated intercellular communication that occurs in the "immunological synapse". This is the contact area of cell-cell conjugates where information is transferred via segregated clusters of proteins. Vast experimental datasets on its assembly are available, and mathematical and computational modeling represent a useful tool to integrate all this information. We created a stochastic computer simulation to study immunological synapse formation. Using this simulation we show that the initial locations of adhesion molecules and T cell receptors (TCRs) at the moment of contact influence the inversion of the immature synapse into a mature synapse, and that movement of large clusters of TCRs towards the center of the contact area accelerates this inversion.
UR - http://www.scopus.com/inward/record.url?scp=50849120718&partnerID=8YFLogxK
U2 - 10.1109/LSSA.2007.4400878
DO - 10.1109/LSSA.2007.4400878
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AN - SCOPUS:50849120718
SN - 9781424418138
T3 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
SP - 35
EP - 38
BT - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
PB - IEEE Computer Society
T2 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
Y2 - 8 November 2007 through 9 November 2007
ER -