Methotrexate embryopathy after exposure to low weekly doses in early pregnancy

María Cecilia Martín, Pablo Barbero, Boris Groisman, Miguel Ángel Aguirre, Gideon Koren

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective: Methotrexate (MTX) is a potent teratogen when used in high doses for cáncer or termination of tubal pregnancy. In contrast, it has been perceived as safe when used once weekly at low dose for rheumatological conditions. Methods: A prospective observational controlled study of women exposed to low dose MTX. The control group were women exposed to MTX only before conception. Results: Among the 8 MTX-exposed pregnancies, there was a case of typical MTX embryopathy, the first to be described to date at this lower once weekly dose Schedule. Conclusions: This case has important implications for rheumatologists treating women of reproductive age, as the assumption of fetal safety of MTX, implied from small cohorts, is premature.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalReproductive Toxicology
StatePublished - Jan 2014
Externally publishedYes


  • Aminopterin embryopathy
  • Methotrexate
  • Pregnancy
  • Rheumatoid arthritis


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