Metabolic regulation by p53 family members

Celia R. Berkers, Oliver D.K. Maddocks, Eric C. Cheung, Inbal Mor, Karen H. Vousden

Research output: Contribution to journalReview articlepeer-review

363 Scopus citations


The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs.

Original languageEnglish
Pages (from-to)617-633
Number of pages17
JournalCell Metabolism
Issue number5
StatePublished - 5 Nov 2013
Externally publishedYes


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