Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission

Itai Levi; Itamar Grotto; Ronit Yerushalmi; Isaac Ben-Bassat; Ofer Shpilberg

doi:10.1016/j.leukres.2003.10.029

Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission

Itai Levi, Itamar Grotto, Ronit Yerushalmi, Isaac Ben-Bassat, Ofer Shpilberg

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR) - 0.95, 95% CI, 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR - 0.82, 95% CI, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission.

Original language	English
Pages (from-to)	605-612
Number of pages	8
Journal	Leukemia Research
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.leukres.2003.10.029
State	Published - Jun 2004
Externally published	Yes

Keywords

ABMT
AML
Acute myeloid leukemia
Autologous bone marrow transplantation
CR
Complete remission
DFS
Disease-free survival
EFS
Event-free survival
HIDAC
High dose cytarabine
IDAC
Intermediate dose cytarabine
LFS
Leukemia-free survival
PBPC

Access to Document

10.1016/j.leukres.2003.10.029

Cite this

@article{3db52780f1ac4745868be1f97ffff3d9,

title = "Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission",

abstract = "In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR) - 0.95, 95% CI, 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR - 0.82, 95% CI, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission.",

keywords = "ABMT, AML, Acute myeloid leukemia, Autologous bone marrow transplantation, CR, Complete remission, DFS, Disease-free survival, EFS, Event-free survival, HIDAC, High dose cytarabine, IDAC, Intermediate dose cytarabine, LFS, Leukemia-free survival, PBPC",

author = "Itai Levi and Itamar Grotto and Ronit Yerushalmi and Isaac Ben-Bassat and Ofer Shpilberg",

year = "2004",

month = jun,

doi = "10.1016/j.leukres.2003.10.029",

language = "אנגלית",

volume = "28",

pages = "605--612",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "6",

}

TY - JOUR

T1 - Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission

AU - Levi, Itai

AU - Grotto, Itamar

AU - Yerushalmi, Ronit

AU - Ben-Bassat, Isaac

AU - Shpilberg, Ofer

PY - 2004/6

Y1 - 2004/6

N2 - In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR) - 0.95, 95% CI, 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR - 0.82, 95% CI, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission.

AB - In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR) - 0.95, 95% CI, 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR - 0.82, 95% CI, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission.

KW - ABMT

KW - AML

KW - Acute myeloid leukemia

KW - Autologous bone marrow transplantation

KW - CR

KW - Complete remission

KW - DFS

KW - Disease-free survival

KW - EFS

KW - Event-free survival

KW - HIDAC

KW - High dose cytarabine

KW - IDAC

KW - Intermediate dose cytarabine

KW - LFS

KW - Leukemia-free survival

KW - PBPC

UR - http://www.scopus.com/inward/record.url?scp=2142708323&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2003.10.029

DO - 10.1016/j.leukres.2003.10.029

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 15120937

AN - SCOPUS:2142708323

SN - 0145-2126

VL - 28

SP - 605

EP - 612

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this