TY - JOUR
T1 - MEPs elicited by multidirectional rotational-field TMS show marked differences compared to unidirectional Figure-of-8 and H7 coils
AU - Sela, Orit Wonderman Bar
AU - Geva, Shay Ofir
AU - Pell, Gaby S.
AU - Roth, Yiftach
AU - Friedman, Jason
AU - Muhana, Afnan
AU - Frenkel-Toledo, Silvi
AU - Soroker, Nachum
N1 - Publisher Copyright:
© 2026 Wonderman Bar Sela et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2026/2
Y1 - 2026/2
N2 - Unidirectional transcranial magnetic stimulation (udTMS; e.g., via Figure-of-8 coil) depolarizes mainly neurons whose axonal orientation aligns with the direction of the induced electric field. A novel dual H-coil (T360°) TMS system (BrainsWayTM, Israel) generates a rotational magnetic field aimed to recruit a larger neuronal population by induction of a multidirectional electric field (rfTMS). This study aimed to comparatively assess the neurophysiological properties of motor evoked potentials (MEPs) elicited from the first dorsal interosseous (FDI) muscle following udTMS (via Figure-of-8 and H7 coils) vs. multidirectional rfTMS. In this study, 10 healthy adult subjects received TMS via the three coil configurations in a random order. The results showed that rfTMS elicited larger MEPs at a lower resting motor threshold (rMT) compared to the unidirectional coils. These findings suggest that rfTMS is likely to recruit larger populations of neurons compared to conventional udTMS coil configurations. This may be advantageous in efforts to enhance motor recovery following brain damage by treatments using TMS.
AB - Unidirectional transcranial magnetic stimulation (udTMS; e.g., via Figure-of-8 coil) depolarizes mainly neurons whose axonal orientation aligns with the direction of the induced electric field. A novel dual H-coil (T360°) TMS system (BrainsWayTM, Israel) generates a rotational magnetic field aimed to recruit a larger neuronal population by induction of a multidirectional electric field (rfTMS). This study aimed to comparatively assess the neurophysiological properties of motor evoked potentials (MEPs) elicited from the first dorsal interosseous (FDI) muscle following udTMS (via Figure-of-8 and H7 coils) vs. multidirectional rfTMS. In this study, 10 healthy adult subjects received TMS via the three coil configurations in a random order. The results showed that rfTMS elicited larger MEPs at a lower resting motor threshold (rMT) compared to the unidirectional coils. These findings suggest that rfTMS is likely to recruit larger populations of neurons compared to conventional udTMS coil configurations. This may be advantageous in efforts to enhance motor recovery following brain damage by treatments using TMS.
UR - https://www.scopus.com/pages/publications/105031073359
U2 - 10.1371/journal.pone.0343725
DO - 10.1371/journal.pone.0343725
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C2 - 41746909
AN - SCOPUS:105031073359
SN - 1932-6203
VL - 21
JO - PLOS ONE
JF - PLOS ONE
IS - 2 February
M1 - e0343725
ER -