TY - JOUR
T1 - Medications That Can Be Fatal for a Toddler with One Tablet or Teaspoonful
T2 - A 2004 Update
AU - Bar-Oz, Benjamin
AU - Levichek, Zina
AU - Koren, Gideon
N1 - Funding Information:
The study was partially supported by Jonathan’s Alert, The Hospital for Sick Children, Toronto. Gideon Koren is a senior scientist of the Canadian Institutes for Health Research.
PY - 2004
Y1 - 2004
N2 - Objective: To provide an updated list of the highly toxic medications in North America that can kill a 10kg toddler upon ingestion of 1-2 dose units. Methods: All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America were subsequently identified, followed by those dose units that could kill a toddler upon ingestion of 1-2 dose units or teaspoonfuls. Results: Tricyclic antidepressants, antipsychotics, quinine derivatives, calcium channel blockers, opioids, and oral hypoglycemics can kill a toddler with 1-2 dose units. This list of drugs was responsible for 40% of toddler fatalities reported to the American Association of Poison Control Center Toxic Exposure Surveillance System between 1990-2000. Conclusion: Drugs that can kill a toddler with 1-2 dose units should be known to clinicians as such exposures warrant immediate and intensive management. A new system of special labeling of these drugs should be considered.
AB - Objective: To provide an updated list of the highly toxic medications in North America that can kill a 10kg toddler upon ingestion of 1-2 dose units. Methods: All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America were subsequently identified, followed by those dose units that could kill a toddler upon ingestion of 1-2 dose units or teaspoonfuls. Results: Tricyclic antidepressants, antipsychotics, quinine derivatives, calcium channel blockers, opioids, and oral hypoglycemics can kill a toddler with 1-2 dose units. This list of drugs was responsible for 40% of toddler fatalities reported to the American Association of Poison Control Center Toxic Exposure Surveillance System between 1990-2000. Conclusion: Drugs that can kill a toddler with 1-2 dose units should be known to clinicians as such exposures warrant immediate and intensive management. A new system of special labeling of these drugs should be considered.
UR - http://www.scopus.com/inward/record.url?scp=1842763590&partnerID=8YFLogxK
U2 - 10.2165/00148581-200406020-00005
DO - 10.2165/00148581-200406020-00005
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C2 - 15035652
AN - SCOPUS:1842763590
SN - 1174-5878
VL - 6
SP - 123
EP - 126
JO - Paediatric Drugs
JF - Paediatric Drugs
IS - 2
ER -