TY - JOUR
T1 - Lung tissue concentrations of nicotine in sudden infant death syndrome (SIDS)
AU - McMartin, Kristen I.
AU - Platt, Marvin S.
AU - Hackman, Richard
AU - Klein, Julia
AU - Smialek, John E.
AU - Vigorito, Robert
AU - Koren, Gideon
N1 - Funding Information:
Supported in part by the Brain and Tissue Bank for Developmental Disorders (NICHHD contract N01-HD8-3283), and the Canadian Institutes for Health Research. Dr McMartin was supported by a studentship of the Canadian Foundation for the Study of Infant Deaths.
PY - 2002
Y1 - 2002
N2 - Objective: To compare lung concentrations of nicotine and cotinine in cases of sudden infant death syndrome (SIDS) and controls. Design/methods: We measured lung tissue concentrations of nicotine and cotinine in SIDS (n = 44) and non-SIDS cases (n = 29) stratified according to household smoking status. Results: When all the SIDS and non-SIDS cases were compared regardless of smoking status, there was a significantly higher nicotine concentration in the SIDS cases than in the non-SIDS cases, (P = .0001). Upon stratifying for smoking status, there was a nonsignificant trend toward more nicotine in SIDS versus non-SIDS lungs that had come from a reported smoking environment. In the nonsmoking group, there were significantly higher nicotine concentrations in SIDS than non-SIDS cases (P = .001). Conclusions: Children who died from SIDS tended to have higher concentrations of nicotine in their lungs than control children, regardless of whether smoking was reported. These results are based on an objective, biochemical test rather than history, and they further support the relationship between environmental tobacco smoke and the risk of SIDS.
AB - Objective: To compare lung concentrations of nicotine and cotinine in cases of sudden infant death syndrome (SIDS) and controls. Design/methods: We measured lung tissue concentrations of nicotine and cotinine in SIDS (n = 44) and non-SIDS cases (n = 29) stratified according to household smoking status. Results: When all the SIDS and non-SIDS cases were compared regardless of smoking status, there was a significantly higher nicotine concentration in the SIDS cases than in the non-SIDS cases, (P = .0001). Upon stratifying for smoking status, there was a nonsignificant trend toward more nicotine in SIDS versus non-SIDS lungs that had come from a reported smoking environment. In the nonsmoking group, there were significantly higher nicotine concentrations in SIDS than non-SIDS cases (P = .001). Conclusions: Children who died from SIDS tended to have higher concentrations of nicotine in their lungs than control children, regardless of whether smoking was reported. These results are based on an objective, biochemical test rather than history, and they further support the relationship between environmental tobacco smoke and the risk of SIDS.
UR - http://www.scopus.com/inward/record.url?scp=0036186172&partnerID=8YFLogxK
U2 - 10.1067/mpd.2002.121937
DO - 10.1067/mpd.2002.121937
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C2 - 11865272
AN - SCOPUS:0036186172
SN - 0022-3476
VL - 140
SP - 205
EP - 209
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -