Long-term effect of verapamil in hypertrophic cardiomyopathy

Y. Hasin; B. S. Lewis; N. Lewis; A. T. Weiss; M. S. Gotsman

doi:10.1016/0167-5273(82)90085-7

Long-term effect of verapamil in hypertrophic cardiomyopathy

Y. Hasin, B. S. Lewis, N. Lewis, A. T. Weiss, M. S. Gotsman

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Abstract

We studied the long-term effects of oral verapamil (240-720 mg) daily on 10 patients with hypertrophic cardiomyopathy. Symptomatic improvement of chest pain or shortness of breath occurred in all the patients although 4 deteriorated after 1 year. Side effects occurred in 3 patients. The electrocardiogram improved in 4 subjects. Quantitative echocardiography showed a significant (P<0.05) decrease in left ventricular contractility (% ΔS decreased from 44±9 to 38±9, mean±SD), septal hypertrophy (1.6±0.5 to 1.4±0.5 cm) and % thickening of the left ventricular free wall (79±29 to 57±22). There was also moderate evidence of improvement in left ventricular compliance; mitral valve EF slope increased from 38 to 55 mm/sec and left atrial diameter decreased.

Original language	English
Pages (from-to)	243-251
Number of pages	9
Journal	International Journal of Cardiology
Volume	1
Issue number	3-4
DOIs	https://doi.org/10.1016/0167-5273(82)90085-7
State	Published - 1982
Externally published	Yes

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title = "Long-term effect of verapamil in hypertrophic cardiomyopathy",

abstract = "We studied the long-term effects of oral verapamil (240-720 mg) daily on 10 patients with hypertrophic cardiomyopathy. Symptomatic improvement of chest pain or shortness of breath occurred in all the patients although 4 deteriorated after 1 year. Side effects occurred in 3 patients. The electrocardiogram improved in 4 subjects. Quantitative echocardiography showed a significant (P<0.05) decrease in left ventricular contractility (% ΔS decreased from 44±9 to 38±9, mean±SD), septal hypertrophy (1.6±0.5 to 1.4±0.5 cm) and % thickening of the left ventricular free wall (79±29 to 57±22). There was also moderate evidence of improvement in left ventricular compliance; mitral valve EF slope increased from 38 to 55 mm/sec and left atrial diameter decreased.",

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AU - Hasin, Y.

AU - Lewis, B. S.

AU - Lewis, N.

AU - Weiss, A. T.

AU - Gotsman, M. S.

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AB - We studied the long-term effects of oral verapamil (240-720 mg) daily on 10 patients with hypertrophic cardiomyopathy. Symptomatic improvement of chest pain or shortness of breath occurred in all the patients although 4 deteriorated after 1 year. Side effects occurred in 3 patients. The electrocardiogram improved in 4 subjects. Quantitative echocardiography showed a significant (P<0.05) decrease in left ventricular contractility (% ΔS decreased from 44±9 to 38±9, mean±SD), septal hypertrophy (1.6±0.5 to 1.4±0.5 cm) and % thickening of the left ventricular free wall (79±29 to 57±22). There was also moderate evidence of improvement in left ventricular compliance; mitral valve EF slope increased from 38 to 55 mm/sec and left atrial diameter decreased.

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Long-term effect of verapamil in hypertrophic cardiomyopathy

Abstract

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