TY - JOUR
T1 - Lead exposure, gestational hypertension and pre-eclampsia
T2 - A systematic review of cause and effect
AU - Kennedy, D. A.
AU - Woodland, C.
AU - Koren, G.
N1 - Funding Information:
Declaration of interest: Deborah Kennedy is supported by a career development grant from the Sickkids Foundation. Gideon Koren holds the Research Leadership for Better Pharmacotherapy During Pregnancy and Breastfeeding (The Hospital for Sick Children) and the Ivey Chair in Molecular Toxicology (University of Western Ontario). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
PY - 2012/8
Y1 - 2012/8
N2 - The association between lead and hypertension in adults was first identified in the early 1980's and it has since been proposed that lead may also have a role in gestational hypertension (GH). This systematic review investigates whether lead may be associated with the development of GH or pre-eclampsia. MEDLINE, Embase and Web of Science were searched from inception to August 2011, using the terms: blood lead levels, pregnancy, pregnancy induced hypertension, gestational hypertension and pre-eclampsia. Nine papers were found. Positive associations between lead and GH or pre-eclampsia were found in six studies. The development of GH or pre-eclampsia may serve as a signal to assess blood lead concentrations in pregnant women, as even low lead concentrations have been shown to negatively impact the neurodevelopment and cognitive abilities of children. Adequate calcium intake throughout the pregnancy and lactation period may assist with reducing lead exposure levels.
AB - The association between lead and hypertension in adults was first identified in the early 1980's and it has since been proposed that lead may also have a role in gestational hypertension (GH). This systematic review investigates whether lead may be associated with the development of GH or pre-eclampsia. MEDLINE, Embase and Web of Science were searched from inception to August 2011, using the terms: blood lead levels, pregnancy, pregnancy induced hypertension, gestational hypertension and pre-eclampsia. Nine papers were found. Positive associations between lead and GH or pre-eclampsia were found in six studies. The development of GH or pre-eclampsia may serve as a signal to assess blood lead concentrations in pregnant women, as even low lead concentrations have been shown to negatively impact the neurodevelopment and cognitive abilities of children. Adequate calcium intake throughout the pregnancy and lactation period may assist with reducing lead exposure levels.
KW - Blood lead concentrations
KW - Exposure
KW - Gestational hypertension
KW - Lead
KW - Pre-eclampsia
UR - http://www.scopus.com/inward/record.url?scp=84863748701&partnerID=8YFLogxK
U2 - 10.3109/01443615.2012.693987
DO - 10.3109/01443615.2012.693987
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 22779950
AN - SCOPUS:84863748701
SN - 0144-3615
VL - 32
SP - 512
EP - 517
JO - Journal of Obstetrics and Gynaecology
JF - Journal of Obstetrics and Gynaecology
IS - 6
ER -