Ketamine upregulates eNOS expression in human astroglial A172 cells: Possible role in its antidepressive properties

Yael Yuhas, Shai Ashkenazi, Eva Berent, Abraham Weizman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 astroglial cells. Ketamine (50–500 μM) increased eNOS expression at 4–24 h in a concentration-dependent manner. This effect was mediated by NMDA receptor, Akt inhibition and ERK1/2 activation and was synergistically augmented by rapamycin. The combined effect on the vascular, immune and neuronal systems may be relevant to the rapid antidepressive effect of ketamine.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalJournal of Neuroimmunology
Volume305
DOIs
StatePublished - 15 Apr 2017
Externally publishedYes

Keywords

  • Inflammation
  • Ketamine
  • Major depressive disorder
  • Nitric oxide
  • eNOS

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